Still, race is expected to be an important topic both nights, especially with the debates in Detroit, a city where four out of five residents are black.
The ability to connect with black voters remains one of the biggest question marks for the three candidates at the center of the stage: Pete Buttigieg, the mayor of South Bend, Ind., who had to defend the lack of diversity in his police force in the first debate; Mr. Sanders, who lost among black voters overwhelmingly to Hillary Clinton in 2016; and Ms. Warren, who has pushed aggressively to define her agenda as focused on both economic and racial justice.
[The democratic debate lineups could lead to fireworks. Here’s why.]
Can O’Rourke stop his slide?
In the June presidential debate, Beto O’Rourke, the former congressman whose campaign has struggled to gain traction, did not land the breakout moment that he needed. Instead, he found himself locked in a tense exchange over immigration with the former housing secretary Julián Castro, a fellow Texan. 
Since then Mr. O’Rourke posted fund-raising numbers that fell far short of what the top-tier contenders landed, coming in with only $3.6 million. He currently hovers at between 2 percent and 3 percent in many polls.
Mr. O’Rourke proved in his 2018 Senate race that he was capable of generating viral moments. Can he find a way to stand out onstage and invigorate his campaign?
Will CNN’s tight leash work?
There will be some changes to the second round of debates, moderated by CNN. For one thing, they’ll be longer: 2 hours of debate time in addition to opening and closing statements. (The NBC debate was 2 hours total, and only had a closing statement.) For another, there will be 60-second opening and closing statements. And in between, CNN has promised there will be no “show-of-hands” questions or queries requesting a single-word answer, which NBC used often in the first set of debates.